The Quest for Cellular Markers of HIV Reservoirs: Any Color You Like.
Antiretroviral therapy (ART) suppress the replication of human immunodeficiency virus (HIV) and improve immune function, but it can not eradicate the virus. Therefore, HIV drug development has become one of the main priorities for research on HIV.
The main obstacle to cure HIV is the establishment of latent viral reservoirs, where the virus is able to “hide” despite decades of therapy, only to reignite active replication once the therapy is stopped. Reveal HIV hideout thus HIV drug research center, but the absence of these cell markers reservoir greatly complicates the search for a cure.
The identification of one or more marker (s) of cells latently infected will represent a significant step forward towards a better explanation of the types of cells involved and improved understanding of HIV latency. Moreover, it could provide a “handle” for selective therapeutic targeting of the reservoir.
A number of cellular markers of HIV reservoirs have recently been proposed, including immune checkpoint molecules, CD2, and CD30. CD32a perhaps the most promising of markers of HIV reservoir as reported related to the enrichment of highly prominent in the HIV DNA, although this finding has been challenged. In this review, we provide an update on the current knowledge about HIV reservoirs marker. We specifically highlight the research characterized continuous cell markers were infected in the lymphoid tissue.
Ligand-Driven and Full-Color-tunable Fiber Source: Toward Next-Generation Fiber-Endoscopy Clinic Tomography with Resolution Mobile.
In many biomedical applications, full-color wide emissions is important, especially for wavelengths below 450 nm, which is difficult to cover through supercontinuum generation. single-crystal sapphire-core with disabilities are encouraged emissions have a potential role in the development of next-generation broadband light source because of their disability centers showed some emission band with customized ligand field.
However, the inability to achieve high quantum results with high crystallinity by blocking the conventional methods of application of ultra-broadband emission. Here, we present how fiber drawing processes an effective step, followed by a thermal treatment is simple and controllable, allowing low-loss, full-color, and plant fiber-based crystal with color variability substantial.
The wide spectrum extending from 330 nm, which is more than 50 nm further into the UV region of the results previously reported. Predicted submicrometer spatial resolution showed that the disability field-ligand potentially beneficial to achieve in vivo cellular tomography. It is also noted that the efficiency of generation of full-color milliwatt level, with the optical efficiency-to-optical nearly 5%, is the highest among the active waveguide of the existing scheme.
Sodium Pyruvate Solution, 100 mM Solution |
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| CCM1753-100 | Bio Basic | 100 mL | 60.84 EUR |
Stop Solution |
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| F006 | Cygnus Technologies | 12 ml | 180 EUR |
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Description: Stop Solution by Cygnus Technologies is available in Europe via Gentaur. |
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DTT Solution |
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| R-1104 | EpiGentek | 1 ml, 500 mM | 109.45 EUR |
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Description: fast delivery possible |
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Denaturing solution |
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| DE540 | Bio Basic | 1L | 61.31 EUR |
AlphaBioCoat Solution |
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| AC001 | Neuromics | 20 ml | 271 EUR |
TRIMMING SOLUTION |
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| 99-676-CM | CORNING | 1 L /pk | 88 EUR |
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Description: Specialty Media; Islet products |
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Schiff's Solution |
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| SRF030 | ScyTek Laboratories | 30 ml | 64 EUR |
Schiff's Solution |
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| SRF250 | ScyTek Laboratories | 250 ml | 77 EUR |
Schiff's Solution |
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| SRF3800 | ScyTek Laboratories | 1 Gal. | 345 EUR |
Schiff's Solution |
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| SRF500 | ScyTek Laboratories | 500 ml | 103 EUR |
Schiff's Solution |
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| SRF999 | ScyTek Laboratories | 1000 ml | 149 EUR |
Tartrazine Solution |
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| TZQ125 | ScyTek Laboratories | 125 ml | 64 EUR |
Tartrazine Solution |
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| TZQ500 | ScyTek Laboratories | 500 ml | 98 EUR |
Tartrazine Solution |
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| TZQ999 | ScyTek Laboratories | 1000 ml | 127 EUR |
Orcein Solution |
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| OAA125 | ScyTek Laboratories | 125 ml | 66 EUR |
Orcein Solution |
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| OAA500 | ScyTek Laboratories | 500 ml | 109 EUR |
Orcein Solution |
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| OAA999 | ScyTek Laboratories | 1000 ml | 148 EUR |
Methenamine Solution |
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| MET125 | ScyTek Laboratories | 125 ml | 64 EUR |
Methenamine Solution |
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| MET500 | ScyTek Laboratories | 500 ml | 95 EUR |
Methenamine Solution |
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| MET999 | ScyTek Laboratories | 1000 ml | 132 EUR |
Borax Solution |
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| BOR015 | ScyTek Laboratories | 15 ml | 56 EUR |
Borax Solution |
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| BOR125 | ScyTek Laboratories | 125 ml | 79 EUR |
Borax Solution |
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| BOR500 | ScyTek Laboratories | 500 ml | 119 EUR |
Borax Solution |
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| BOR999 | ScyTek Laboratories | 1000 ml | 183 EUR |
SDS Solution |
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| 2102-100 | Biovision | 137 EUR | |
EDTA Solution |
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| 2103-100 | Biovision | 137 EUR | |
Prehybridization Solution |
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| K2191050-1 | Biochain | 5 ml | 137 EUR |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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Hybridization Solution |
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| K2191050-2 | Biochain | 5 ml | 157 EUR |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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Blocking Solution |
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| K2191050-8 | Biochain | 250 ul | 137 EUR |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit |
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| CAS400A-KIT | SBI | 1 kit (10 rxn) | 1110 EUR |
CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV100PA-KIT | SBI | 1 Kit | 1132 EUR |
CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV105PA-KIT | SBI | 1 Kit | 1132 EUR |
MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV120PA-KIT | SBI | 1 Kit | 1132 EUR |
MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV125PA-KIT | SBI | 1 Kit | 1132 EUR |
Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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| CAS700A-KIT | SBI | 10 rxn | 1132 EUR |
Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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| CAS720A-KIT | SBI | 10 rxn | 1132 EUR |
Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector |
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| CAS740A-KIT | SBI | 10 rxn | 1132 EUR |
T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents) |
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| CAS510A-KIT | SBI | 1 Kit | 805 EUR |
Gentamicin Solution, Gentamicin Solution, 50 mg/mL |
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| CCM1123-010 | Bio Basic | 10 mL | 64.05 EUR |
Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV200PA-KIT | SBI | 1 Kit | 1132 EUR |
Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV205PA-KIT | SBI | 1 Kit | 1132 EUR |
Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV220PA-KIT | SBI | 1 Kit | 1132 EUR |
Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit |
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| CASLV225PA-KIT | SBI | 1 Kit | 1132 EUR |
Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector |
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| CAS750A-KIT | SBI | 10 rxn | 1132 EUR |
Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector |
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| CAS770A-KIT | SBI | 10 rxn | 1132 EUR |
Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector |
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| CAS790A-KIT | SBI | 10 rxn | 1132 EUR |
Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)] |
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| CAS9LIG-KIT | SBI | 1 Kit | 153 EUR |
Dr. P Kit-Solution 1 |
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| K2021010-1 | Biochain | 50 ml | 204 EUR |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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Dr. P Kit-Solution 2 |
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| K2021010-2 | Biochain | 6 ml | 120 EUR |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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Dr. P Kit-Solution 3 |
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| K2021010-3 | Biochain | 50 ml | 133 EUR |
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Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
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PinPoint-FC 293T Platform Kit for Targeted Gene Insertion (includes PIN320A-1, PIN200A-1, PIN510A-1 & PIN600A-1) |
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| PIN320A-KIT | SBI | 1 Kit | 4941 EUR |
PinPoint-FC Murine iPSC Platform Kit for Targeted Gene Insertion (includes PIN340iPS-1, PIN200A-1, PIN510A-1 & PIN600A-1) |
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| PIN340iPS-KIT | SBI | 1 Kit | 4941 EUR |
Stop Solution, 25ML |
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| X020-25ML | Arbor Assays | 25ML | 109 EUR |
Stop Solution, 5ML |
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| X020-5ML | Arbor Assays | 5ML | 65 EUR |
Stop Solution, 1ML |
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| X046-1ML | Arbor Assays | 1ML | 65 EUR |
Creatinine Solution, 100ML |
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| X116-100ML | Arbor Assays | 100ML | 131 EUR |
Creatinine Solution, 25ML |
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| X120-25ML | Arbor Assays | 25ML | 173 EUR |
Extraction Solution, 250ML |
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| X123-250ML | Arbor Assays | 250ML | 263 EUR |
Extraction Solution, 50ML |
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| X123-50ML | Arbor Assays | 50ML | 123 EUR |
Mesotocin Solution, 625UL |
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| X127-625UL | Arbor Assays | 625UL | 227 EUR |
Isotocin Solution, 625UL |
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| X128-625UL | Arbor Assays | 625UL | 227 EUR |
Stop Solution, 5ML |
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| X134-5ML | Arbor Assays | 5ML | 65 EUR |
RNA Stabilization Solution |
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| FARSS-001 | Favorgen | 100ml | 208 EUR |
Glutaraldehyde, 50% solution |
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| G0875 | Bio Basic | 25ml | 60.44 EUR |
Glutaraldehyde, 25% solution |
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| GC3870 | Bio Basic | 100ml | 60.44 EUR |
calibration solution ammonium |
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| ISC20 | Consort | ea | 91 EUR |
calibration solution bromide |
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| ISC21 | Consort | ea | 91 EUR |
calibration solution calcium |
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| ISC23 | Consort | ea | 91 EUR |
calibration solution chloride |
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| ISC24 | Consort | ea | 91 EUR |
calibration solution cupric |
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| ISC25 | Consort | ea | 91 EUR |
calibration solution fluoride |
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| ISC27 | Consort | ea | 91 EUR |
calibr. solution fluoroborate |
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| ISC28 | Consort | ea | 91 EUR |
calibration solution iodide |
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| ISC29 | Consort | ea | 91 EUR |
calibration solution nitrate |
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| ISC31 | Consort | ea | 91 EUR |
cal. solution perchlorate |
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| ISC32 | Consort | ea | 91 EUR |
cal. solution potassium |
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| ISC33 | Consort | ea | 91 EUR |
calibration solution silver |
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| ISC34 | Consort | ea | 91 EUR |
calibration solution sodium |
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| ISC35 | Consort | ea | 91 EUR |
cal. solution surfactant |
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| ISC36 | Consort | ea | 91 EUR |
calibration solution ammonia |
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| ISC50 | Consort | ea | 91 EUR |
Glyoxal, 40% solution |
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| D0238 | Bio Basic | 1Kg | 75.91 EUR |
1L Denaturation Solution |
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| NAT1232 | National Diagnostics | 1L | 85 EUR |
1L Neutralization Solution |
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| NAT1234 | National Diagnostics | 1L | 85 EUR |
100ML Eosin Solution |
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| NAT1340 | National Diagnostics | 100ML | 89 EUR |
Ponceau S Solution |
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| P9100-002 | GenDepot | 20ml | 68 EUR |
Ponceau S Solution |
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| P9100-010 | GenDepot | 100ml | 91 EUR |
Ponceau S Solution |
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| P9100-050 | GenDepot | 500ml | 155 EUR |
10% SDS Solution |
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| S0792-050 | GenDepot | 500ml | 93 EUR |
10% SDS Solution |
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| S0792-100 | GenDepot | 2X500ml | 122 EUR |
20% SDS Solution |
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| S0793-050 | GenDepot | 500ml | 120 EUR |
20% SDS Solution |
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| S0793-100 | GenDepot | 2X500ml | 166 EUR |
Smooth Coat Solution |
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| SC300 | Neuromics | 20 ml | 257 EUR |
In addition, the direct evidence of a high-resolution transmission electron microscopy together with electron energy loss spectroscopy and crystal-field ligands revealed a very good nucleus of crystal, atoms defined core / cladding interface roughness, and significant enhancements to the electronic defect levels laser- new induced. Our work shows that cheap, smooth, and highly scalable route to achieving a resolution tomographic imaging of cells and is an important step in the development of diagnostic endoscopy-compatible devices.